Mohammad Reza Hashemzadeh
PhD Candidate, Department of Stem Cells and Regenerative Medicine, Royesh Stem Cell Biotechnology Institute, Mashhad, Iran
Title: Stem Cells and Regenerative Medicine: The Potential Aspects in Cardiovascular System
Biography
Biography: Mohammad Reza Hashemzadeh
Abstract
Stem cells have a key role in therapeutic field in today’s world. Regenerative medicine is a vast realm in which stem cells are recruited as source of tissue regeneration in most of organs especially in heart and cardiovascular system where cardiovascular diseases are the leading cause of mortality in recent years. The numerous types of stem cells such as embryonic stem cells and adult stem cells have been used in regenerative medicine especially in cardiovascular diseases and there are different routes of delivering cells to heart as a target tissue. Notwithstanding that using stem cells is a decent procedure, in some cases this is inefficient due to lack of targeted localization. This issue can be solved with triggering of CXCR4/SDF1 axis in these cells in order to stimulating of targeted mobilization and directing towards target tissue. Another aspect of regenerative medicine is the up-regulation and downregulation of microRNAs during stem cell differentiation and in cardiovascular diseases. On the other hand, the base of the majority of myocardial ischemia is inflammation and it sounds that the evaluation and manipulation of some immunological key genes such as toll like receptors and downstream elements in differentiation of stem cells into cardiomyocytes can be appropriate in therapeutic targets of cardiovascular diseases.