World Congress on Stem Cell Biology and Biobanking September 03-04, 2018 Tokyo, Japan

Biography:

Mohammad Reza Hashemzadeh started his research studies on stem cells from 2005. In 2010, He founded the first biotechnology institute in the ministry of labor and social welfare of Iran, with cooperative of Khorasan Technical and Vocational Training Organization, in Mashhad called Eram biotechnology institute and now he is the head of stem cell department in that institute. Furthermore, He is the founder and director of ROYESH Stem Cell Biotechnology (RSCB) institute in Mashhad. He is interested in stem cells and regenerative medicine especially in cardiovascular diseases. His recent study is the evaluation of TLRs during cardiomyocyte differentiation in order to optimization of regenerative medicine in cardiovascular diseases. Also study of homing of adipose derived MSCs, study of gene regulation in stem cells based on miRNAs and siRNA and identification of a new stem cell line in Rabbit namely blastema stem like cells are another researches which he has done.

Abstract:

Stem cells have a key role in therapeutic field in today’s world. Regenerative medicine is a vast realm in which stem cells are recruited as source of tissue regeneration in most of organs especially in heart and cardiovascular system where cardiovascular diseases are the leading cause of mortality in recent years. The numerous types of stem cells such as embryonic stem cells and adult stem cells have been used in regenerative medicine especially in cardiovascular diseases and there are different routes of delivering cells to heart as a target tissue. Notwithstanding that using stem cells is a decent procedure, in some cases this is inefficient due to lack of targeted localization.  This issue can be solved with triggering of CXCR4/SDF1 axis in these cells in order to stimulating of targeted mobilization and directing towards target tissue. Another aspect of regenerative medicine is the up-regulation and downregulation of microRNAs during stem cell differentiation and in cardiovascular diseases. On the other hand, the base of the majority of myocardial ischemia is inflammation and it sounds that the evaluation and manipulation of some immunological key genes such as toll like receptors and downstream elements in differentiation of stem cells into cardiomyocytes can be appropriate in therapeutic targets of cardiovascular diseases.

Biography:

Jonathan Schwartz has over 37 years in Healthcare, Globalizing Emerging Medical Technologies, and has devoted the past eight years to Commercializing Cellular Therapies and Regenerative Medicine Technologies. He has been instrumental in introducing new technologies worldwide and is universally acknowledged as a pioneer in emerging medical technology. He has lectured extensively, edited publications and authored many articles.

Abstract:

Innovations and Breakthroughs for Enhancement of Stem Cell Procedures

The topic of this presentation will be devoted to recent developments in technology to enhance Cellular Therapies and what is currently commercially available.

Technologies include the following:

Nitric Oxide

Intraveneous Laser Blood Irradiation

Shock Therapy

Molecular Hydrogen Therapy

New Methods of Harvesting Stem Cells from

1. Adipose Tissue
2. Bone Marrow
3. Dental Pulp

Supplements

Exosomes

Cytokines

How they can be incorporated and combined to enhance Stem Cell Procedures

Biography:

Tomasz OÅ‚dak has completed his PhD at the age of 29 years from Institute of Hygiene and Epidemiology, Warsaw, Polamd. He is a director of Research and Development Department of Polish Stem Cell Bank. He has published 22 papers in reputed journals.

Abstract:

Alzheimer’s Disease is a non treatable condition affecting more and more people every year. There are many clinical trials concerning treatment of this disease, but none has finished with positive results so far. The aim of this study was to evaluate possible correlations between Alzheimer’s Disease and the alterations in cytokine/chemokine level in the serum of 20 patients in the various stage of the disease and 10 healthy volunteers as a control. The stem cell therapy is a very fast developing branch of medicine. Very interesting from the scientific point of view seem to be the co-culture of stem cells and limfocytes obtaining from patients and healthy donors. Cord tissue was the source of mesenchymal stromal cells (MSC). Investigated interactions between MSC and limfocytes was measured by obtaining supernatant after 1, 3, and 7 days of co-culture. The conditions allowed or preserve of direct cell-to-cell interaction from paracrinne effect due to physical barriers. The preliminary findings of this investigation showed interesting relations between cells resulting in cytokine levels. One of the proposed explanation of beta-amyloid plaques creation is the dysregulation of immunological system. Th2 lymphocytes cannot compensate increased activity of Th1 lymphocytes and their overproduction of proinflamatory cytokines. This situation has the negative outcomes. It is the inability to control the production of beta-amyloid that in particular is not eliminated and leads to neuronal death. Additional is microglia incorrect activity which is able in physiological conditions to establish protein homeostasis in central nervous system.